Syndrome Genes Could Be Turned Off for the Purpose of Learning

Question:-

Can you describe the process by which the Down syndrome genes could be turned off for the purpose of learning concepts in genetics? How can this be helpful or harmful physiologically?

Answer:-

One’s body already has its way in silencing the extra chromosome; this gene is known as XIST, turning off the X chromosome of the second among females. It shuts the chromosome, covering other molecules not producing proteins. The patients keep having 2 instead of the 2 copies for chromosome 21 usually. This results in issues where the brain and body develop (Wiseman et al., 2018). From Down patients, utilizing cells, the Massachusetts University scientists kept transplanting this XIST gene into the 3^rd copy. This gene, sure enough, kept silencing this extra chromosome causing Down which allows those cells in growing way rapidly in this laboratory, suggesting upon functions greatly. Though this technique is not the cure, this aids researchers in understanding the condition effects upon cells greatly with designing treatment for the symptoms.

Few of the researchers mention upon the gene therapy in this matter requires in carefulness to avoid any gene toxicity through these approaches. For instance, this means upon the chromosome removal should not keep rearranging or breaking the genetic code remains. This turning off of that gene should not do this. In researches, with focussing on myeloid differentiation, these hematopoietic progenitors studies with trisomy silencing correction cause harms (Benn et al., 2019). These can give rise to the lymphoid system. Those abilities in transcriptome normalization keep mitigating immune defects like autoimmune defects, inflammation and higher viral susceptibility. Several recent studies, furthermore, keep suggesting the links among neurodegenerative diseases, inflammation and immune system. This goes for the Alzheimer’s disease having prevalence within Down syndrome. Apart from these, this would help in identifying the potential targets of drugs.